Epub 2012 Jun 19. Background We examined relapse after response to a first episode of schizophrenia or schizoaffective disorder.. Methods Patients with first-episode schizophrenia were assessed on measures of psychopathologic variables, cognition, social functioning, and biological variables and treated according to a standardized algorithm. Relapse can interfere … 5. In particular, relapse during the first few years after onset of the psychotic episode is an important determinant for long-term clinical and functional outcome. The optimal length of time that maintenance antipsychotic treatment is needed to minimise risk of relapse in first-episode psychosis is not known. 2012 Aug;46(8):1099-105. doi: 10.1016/j.jpsychires.2012.05.001. 2016 Jan;63:262-70. doi: 10.1016/j.psyneuen.2015.10.007. After being identified as having high-risk mental states, or after an initial diagnosis of psychosis, relevant outcomes over the years following include transition to psychosis or schizophrenia, symptom severity, recovery and remission, relapse, employment, functioning, relationships, and quality of life. 2017 Dec;58:59-75. doi: 10.1016/j.cpr.2017.09.007. The aim of this study was to systematically compile and analyse risk factors for and rates of relapse in the early course of psychosis. Medication non-adherence, persistent substance use disorder, carers' critical comments (but not overall expressed emotion) and poorer premorbid adjustment, increased the risk for relapse 4-fold, 3-fold, 2.3-fold and 2.2-fold, respectively. Between 55–70% of. Smartphone-delivered self-management for first-episode psychosis: the ARIES feasibility randomised controlled trial. Preventing relapse is an essential element of early intervention in psychosis, but relevant risk factors and precise relapse rates remain to be clarified. Conclusion: If the treatment of first episode psychosis with antipsychotic medication is stopped for a month or more, remission may be delayed and the risk of relapse following remission may be substantially increased. The purpose of the present study is to determine the rate of relapse after 3 years of a first episode of psychosis and to examine the predictors of an increasing risk of relapse. Preventing the second episode: a systematic review and meta-analysis of psychosocial and pharmacological trials in first-episode psychosis. What is the risk of symptom recurrence after antipsychotic discontinuation in first-episode psychosis? The aim of this study was to systematically compile and analyse risk factors for and rates of relapse in the early course of psychosis. Reconsidering brain tissue changes as a mechanistic focus for early intervention in psychiatry. Systematic review and meta-analysis of English and non-English language, peer-reviewed, longitudinal studies, with a minimum 12-month follow-up and at least 80% of participants diagnosed with a first episode of psychosis (FEP) that reported risk factors for relapse. doi: 10.1136/bmjopen-2019-034927. HHS | Between 55–70% of people with FEP will experience a psychotic relapse within two years of remission of their initial episode. The relapse rate following discontinuation of antipsychotics in people with chronic schizophrenia is around 38%. Results: A total of 220 patients with first-episode psychosis were included in the analysis (mean [SD] age, 28.62 [8.58] years; … Chaumette B, Kebir O, Mam-Lam-Fook C, Morvan Y, Bourgin J, Godsil BP, Plaze M, Gaillard R, Jay TM, Krebs MO. Background We examined relapse after response to a first episode of schizophrenia or schizoaffective disorder.. Methods Patients with first-episode schizophrenia were assessed on measures of psychopathologic variables, cognition, social functioning, and biological variables and treated according to a standardized algorithm. Some women will have only a single episode of post-partum psychosis, while others will have an episode of illness after each time they have a baby. Further, those who used cannabis continually after first-episode psychosis were found to have a 59.1% higher risk of relapsing psychosis in that 10-year period, compared with a 28.5% increased risk in those who quit using cannabis entirely (P less than.001). Copyright © 2020 Elsevier B.V. or its licensors or contributors. Medication non-adherence, persistent substance use disorder, carers' critical comments (but not overall expressed emotion) and poorer premorbid adjustment, increased the risk for relapse 4-fold, 3-fold, 2.3-fold and 2.2-fold, respectively. USA.gov. 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